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No particular dose adjustment advisable when tofacitinib coadministered with strong CYP2C19 inhibitors; lessen tofacitinib dose if coadministered with both reasonable CYP3A4 and potent CYP2C19 inhibitors .fosphenytoin will decrease the level or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track o